What are monocytes?

Monocytes are a type of white blood cell (leukocytes) that reside in your blood and tissues to find and destroy germs (viruses, bacteria, fungi and protozoa) and eliminate infected cells. Monocytes call on other white blood cells to help treat injury and prevent infection.

What do monocytes do?

Monocytes are your cell’s firefighters. Their lifecycle begins in the bone marrow (soft tissue inside of your bones) where they grow and train to protect your body. Once they mature, they enter your bloodstream and tissues to defend your body against foreign invaders, like germs.

Germs are similar to fires when they enter your body. Once germs are inside your tissues, monocytes hear an alarm, calling them into action to fight the fire. These cellular firefighters differentiate into two types of cells:

Dendritic cells: Ask other cells in your immune system for backup to fight germs.

Macrophages: Defend your body from germs on the front lines.

What do dendritic cells do?

Dendritic cells are your fire department’s call center. They're responsible for alerting other cells in your body to help fight infection. Dendritic cells reside in superficial tissues, such as just beneath your skin and in the lining of your nose, lungs, stomach and intestine. When a germ enters the body’s tissues, dendritic cells collect the antigen of the invading germ (the molecule in the germ that produces an antibody response) and release proteins (cytokines) that notify other white blood cells to come to the site of the infection and destroy the invader.

What do macrophages do?

Macrophages are on the front lines of the fire, fighting germs (viruses, bacteria, fungi and protozoa) that enter your body. Macrophage cells surround the invading germ and ingest and kill it with toxic enzymes within the cell. These cells also help remove dead cells from your tissues and bloodstream.

What are the common disorders that affect monocytes?

Conditions vary based on the number of monocytes in your blood. Your monocyte count can be too high or too low as a result of your body fighting an infection or disease.

Monocytosis

Monocytosis occurs when your monocyte count is too high. It's most often linked to a chronic infection or disease that your body is fighting. Causes of monocytosis include:

Autoimmune diseases (lupus, rheumatoid arthritis).

Blood disorders.

Cancer (leukemia, lymphoma).

Cardiovascular disease.

Infection (mononucleosis).

Inflammatory disorder (sarcoidosis).

Monocytopenia

Monocytopenia occurs when your monocyte count is too low. This is the result of decreases in your white blood cell count. Causes of monocytopenia include:

Aplastic anemia.

Blood infection.

Burn injuries.

HIV.

Reaction to chemotherapy.

What is a normal range for my monocyte count?

A normal monocyte count is between 2% and 8% of your white blood cell count. This equals about 200 to 800 monocytes per microliter of blood in healthy adults. If your monocyte count is outside those ranges, you're at risk of acquiring a monocyte-related condition.

What are common symptoms of monocyte conditions?

If you have a low or high monocyte count, you most likely won’t experience any symptoms from the count itself. Instead, any symptoms you might feel are a side effect of a disorder that caused your monocyte count to be abnormal. Symptoms of monocyte disorders include:

Abdominal pain.

Swelling (inflammation).

How do I reduce my high monocyte count?

Treatment to reduce your high monocyte count includes:

Avoiding foods that cause inflammation like red meats, refined carbohydrates and fried foods.

Exercising regularly.

Limiting alcohol consumption.

Managing current medical conditions.

Treating infections with medications where medically appropriate

How do I increase my low monocyte count?

Treatment to increase your low monocyte count includes:

Discussing with your healthcare provider changing dosage or timing of medications that could cause a low monocyte count.

Managing underlying medical conditions.

Taking vitamins to improve your immune system (B12, C, D) if you are deficient.

Treating current infections.

1) https://my.clevelandclinic.org/health/body/22110-monocytes