Comprehensive cell mitosis regulation factor

There are processes of synthesis and destruction of proteins in cells all the time. Destruction occurs mainly in specialized organelle: lysosome.  There are majority of hydrolyzing enzymes and optimal environment for their activity in lysosome.

However, there is a second way of destruction for proteins involved in intracellular regulatory processes. Cyclins belongs to such type of proteins, too. They contain a specific sequence of 8-10 amino acids, which is localized near the N- terminus (nitrogenous terminus) and is called as a destruction block. Mentioned proteins are represented on the level of liver and pancreas functioning, where bradykinin provides necessary contact time for proteolytic factors affecting the proteins.

When the protein must be destroyed, the second protein links to amino acids from destruction block – it’s recognizing protein. This protein is represented in enzymes such as α-trypsin, which consists of 24 amino peptides and 418 linear amino peptides. Mannose-6-phosphate influences to the proteolytic factor that determines the direction of proteolytic reaction. These functions are connected with synthesis and destruction of ubiquitin.

Mechanisms of cells’ mitosis work as a biochemical oscillator which depends on relations between acidic and basic proteins. Metal-enzymes always take part in the division processes. At the same time, oscillator is a series of biochemical reactions, where morphogenetic hormone and comprehensive cell mitosis regulation factor play an important role. In addition, the factor is closely related to cell cycle.

At present time key components of the Comprehensive cell mitosis regulation factor are cyclines (see the picture below). Cyclines are composed of proteins p53, p21, p 15, p16, p27 to ensure accurate replication and distribution of genetic material in cell cycle. Protein p53 is involved into regulation and proliferation of undifferentiated cells.  Protein p21 is activated in aging cells and is involved in the processes of cell growth delay, interacts with protein p53.

Protein p27 interacts with cyclins and provides contact inhibition of cell growth and leaving of cells from the cell cycle. Proteins p15 and p16 interact with and cDk4 cDk6. It is supposed that p15 and p21 proteins may work as delay mediators of cell proliferation and they are connected with transforming growth factor.

Temperature parameters of carotid and abdominal area are related to heat shock proteins Hsp90 and Hsp60 (presumably through the formation of nitric oxide, which is involved into all metabolic regulatory functions of a body).

Cyclines B include two subunits: kinase domain (able to phosphorylate specific substances in a cell) and the regulatory subunit (its synthesis is increasing or decreasing all the time). Taking into account that cycline B has got two subunits, we hypothesized and proved that these units operate in systems of temperature and pH formation.

Hematopoietic cell (blood cell) receives a signal to divide from special cellular protein Ubiquitin, which synthesized and distroyed during biochemical processes in the cell. A feature of such processes is maintaining of constant pH in the cell’s organelles: lysosomes and cytosol. At the same time, when the pH of lysosomes is 5 and pH of cytosol is 7.35, it is provided the interaction between protons of H and H2O, which is realized in the system of Н-О-ОН interrelations (through concentration of protons H, O and OH in lysosomes and cytosol) and we get the final result – temperature.

Ubiquitin, which has a constant mass (kDa 76), is synthesized and destroyed as a result of biochemical reactions determined by genophenotypic information – the ratio of ubiquitin to oxygen. Such information appears under the impact of gaseous compound, atmosphere pressure and light flux of external environment on a body with the forming of a responsive temperature and metabolic reaction with a compulsory involvement of Comprehensive cell mitosis regulation factor, transforming growth factor, structural proteins of erythrocyte’s cell membranes (actin, spectrin and glycophorin), nitrogen oxide and arginine. All these informational processes occur with the compulsory involvement of chemical elements being a part of membrane and organelles of cell structure (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulphur). At the same time, nervous, endocrine, immunological and hematopoietic systems interrelate on the level of comprehensive cells mitosis regulation factor activation. The factor is activated by tyrosine kinase cascade of reactions. Inhibition of the factor occurs with the participation of protein phosphatase.

Abnormalities. Disorders or diseases caused or related.

Low values of this parameter (less than 3.5-3.0) are the signal for a medical professional to verify the presence of any neoplasm. Usually, localisation of possible neoplasm can be found using the parameters listed in the section “Internal blood flow” (ID64-77). Mostly, the involved/affected system of organs has a low value of blood flow.

Significantly elevated levels (more than 4.6-5) in combination with abnormal parameters of blood flow (ID64-77) may characterise the late stages of the oncological disease. As a rule, visible manifestation and signs are present, so a visual examination of the patient or conversation with a patient can clarify the situation.