eGFR [MDRD]

Glomerular filtration rate (GFR) describes the flow rate of filtered fluid through the kidney. GFR is the volume of fluid filtered from the renal (kidney) glomerular capillaries into the Bowman's capsule per unit time. Central to the physiologic maintenance of GFR is the differential basal tone of the afferent and efferent arterioles

Creatinine clearance exceeds GFR due to creatinine secretion, which can be blocked by cimetidine In alternative fashion, overestimation by older serum creatinine methods resulted in an underestimation of creatinine clearance, which provided a less biased estimate of GFRBoth GFR and C_Cr may be accurately calculated by comparative measurements of substances in the blood and urine, or estimated by formulas using just a blood test result (eGFR and eC_Cr).

The results of these tests are important in assessing the excretory function of the kidneys. For example, grading of chronic renal insufficiency and dosage of drugs that are excreted primarily via urine are based on GFR (or creatinine clearance).

Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)) equation, which was developed and validated in the bonds of the National Kidney Disease Education Program (USA)

It is the equation, which we use in our software (excluding factor for black race).

A normal eGFR is 90 or higher, as long as you don't have any other signs of kidney damage. If your eGFR is less than 90 for three months or more, your kidneys may not be working well. Use this chart to see what your eGFR may mean.

Stage 1: eFGR ≥ 90; kidneys work as well as normal

Stage 2: eGFR 60-89; mild kidney damage

Stage 3: eGFR 45-59; mild to moderate kidney damage

Stage 4: eGFR 30-44; moderate to severe kidney damage

Stage 5: eGFR < 15; kidney failure

1.       https://www.kidneyfund.org/all-about-kidneys/tests/egfr/egfr-test-change-removal-race-calculation

2.       Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J, CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)., A new equation to estimate glomerular filtration rate.. Ann Intern Med 2009;150: 604-12PubMed

3.       Stevens LA, Schmid CH, Greene T et al, Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60 mL/min/1.73 m2.. Am J Kidney Dis 2010;56: 486-495PubMed

4.       Kronisk nyresygdom. Analysemetoder og klinisk evaluering. Rekommandationer for vurdering af glomerulær filtrationsrate og albuminuri. Dansk Nefrologisk Selskab, Dansk Pædiatrisk Selskab, Dansk Selskab for Klinisk Biokemi. 2015Vis kilde

5.       Inker LA, Eneanya ND, Coresh J, Tighiouart H, Wang D, Sang Y, Crews DC, Doria A, Estrella MM, Froissart M, Grams ME, Greene T, Grubb A, Gudnason V, Gutiérrez OM, Kalil R, Karger AB, Mauer M, Navis G, Nelson RG, Poggio ED, Rodby R, Rossing P, Rule AD, Selvin E, Seegmiller JC, Shlipak MG, Torres VE, Yang W, Ballew SH, Couture SJ, Powe NR, Levey AS, Chronic Kidney Disease Epidemiology Collaboration., New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race. N Engl J Med 2021;: PubMed

6.       https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810758/

7.       https://pubmed.ncbi.nlm.nih.gov/20483451/