Estimated creatinine clearance rate(eClCr)[Cockroft and Gault]

GFR approximation using Creatinine Clearance

Creatinine is a breakdown product of dietary meat and creatine phosphate found in skeletal muscle. Its production in the body is dependent on muscle mass. The CrCl rate approximates the calculation of GFR since the glomerulus freely filters creatinine. However, it is also secreted by the peritubular capillaries, causing CrCl to overestimate the GFR by approximately 10% to 20%. Despite the marginal error, it is an accepted method for measuring GFR due to the ease of measurement of CrCl.

Cockcroft-Gault formula: Estimated creatinine clearance rate (eClCr)

Creatinine clearance can be estimated using serum creatinine levels. The Cockcroft-Gault (C-G) formula uses a patient’s weight (kg) and gender to predict CrCl (mg/dL). The resulting CrCl is multiplied by 0.85 if the patient is female to correct for the lower CrCl in females. The C-G formula is dependent on age as its main predictor for CrCl. Below is the formula:

eClCr = (140 – Age) x Mass (kg) x [0.85 if female] / 72 x [Serum Creatinine (mg/dL)]

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1.       https://pubmed.ncbi.nlm.nih.gov/31334948/

2.       Schwartz GJ, Haycock GB, Edelmann CM, Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics. 1976 Aug;58(2):259-63. - PubMed

3.       Kampmann JP, Hansen JM. Glomerular filtration rate and creatinine clearance. Br J Clin Pharmacol. 1981 Jul;12(1):7-14. - PMC - PubMed

4.       Gowda S, Desai PB, Kulkarni SS, Hull VV, Math AA, Vernekar SN. Markers of renal function tests. N Am J Med Sci. 2010 Apr;2(4):170-3. - PMC - PubMed

5.       Stevens LA, Coresh J, Greene T, Levey AS. Assessing kidney function--measured and estimated glomerular filtration rate. N Engl J Med. 2006 Jun 08;354(23):2473-83. - PubMed

6.       Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41. - PubMed